Report says Michael Jackson had lethal levels of Propofol

LOS ANGELES—Los Angeles County coroner’s officials found lethal levels of the powerful anesthetic propofol after examining Michael Jackson’s body, according to a search warrant affidavit unsealed Monday in Houston.

According to the search warrant, Jackson’s doctor, Conrad Murray, told Los Angeles Police Department detectives that he had been treating Jackson for insomnia for about six weeks. He had been giving Jackson 50 milligrams of propofol every night using an intravenous line, according to the court records.
But Murray told detectives that he feared Jackson was forming an addiction and began trying to wean the pop star off the drugs. He lowered the dosage to 25 milligrams and mixed it with two other sedatives, lorazepam and midazolam. On June 23, two days before Jackson’s death, he administered two medications and withheld the propofol.

On the morning Jackson died, Murray tried to induce sleep without using propofol, according to the affidavit. He said he gave Jackson Valium at 1:30 a.m. When that didn’t work, he said, he injected lorazepam intravenously at 2 a.m. At 3 a.m., when Jackson was still awake, Murray administered midazolam.

Over the next few hours, Murray said he gave Jackson various drugs. Then at 10:40 a.m., Murray administered 25 milligrams of propofol after Jackson repeatedly demanded the drug, according to the court record.

Although Murray acknowledged to police that he administered Profofol, authorities said they could find no evidence that he had purchased, ordered or obtained the medication under his medical license or DEA tracking number. However, police detectives saw about eight bottles of Propofol in the house along with other vials and pills that had been prescribed to Jackson by Murray, Dr. Arnold Klein and Dr. Allan Metzger.

Other drugs that were confiscated in the search included Valium, Tamsulosin, Lorazepam, Temazepam, Clonazepam, Trazodone and Tizanidine. They also found Propofol in Murray’s medical bag. Murray told detectives that he was not the first doctor to administer the powerful anesthetic to Jackson.

Between March and April 2009, Murray said he called Las Vegas Dr. David Adams at Jackson’s request to arrange for Adams to administer Propofol. Murray said he was present at a cosmetologist’s office, where Adams used Propofol to sedate Jackson. Since he began treating Jackson, Murray said he repeatedly asked the pop star what other physicians were treating Jackson and what drugs they were prescribing. But Jackson declined to provide the information, Murray told authorities.

Murray said he noticed injection marks on Jackson’s hands and feet. When he asked Jackson about them, the pop star told him he had been given a ``cocktail’‘ to help him. In addition to Murray, authorities subpoenaed medical records from Klein, Metzger and Adams, the affidavit states. They also asked for medical records from Dr. David Slavitt, who conducted the independent medical examination of Jakcson for Anschuntz Enetertainment Group, Dr. Randy Rosen and nurse practitioner Cherilyn Lee.They also subpoenaed records from Dr. Mark Tadrissi, who stored medical records with Adams.

Murray has already acknowledged obtaining and administering propofol to Jackson the morning that he died. In an interview with police, Murray told them that he left Jackson alone under the influence of the medication to make telephone calls to his Houston office and family members.

When he returned, he discovered Jackson was not breathing. He performed CPR, and one of Jackson’s staff members called 911. The 50-year-old pop star was rushed to the University of California, Los Angeles, Medical Center, where he later was declared dead. Much of the investigation has focused on propofol—a drug typically administered by anesthesiologists during surgery—and whether Murray’s decision to give it to Jackson as a sleep aid outside a hospital setting reaches a level of negligence required for an involuntary manslaughter charge.